Zhuqiu (James) Jin, PhD

Department of Pharmaceutical and Biomedical Sciences
Associate Professor-Pharmacology

Phone: (916) 686-7690
Fax: (916) 686-8142
Zhuqiu.Jin@cnsu.edu

About

Zhuqiu (James) Jin is a Professor of Pharmacology and Vice Chair in the Department of Pharmaceutical & Biomedical Sciences at California Northstate University College of Pharmacy (CNUCOP). He obtained his M.S. degree in Pharmacology from Shenyang Pharmaceutical University and his Ph.D. degree in Pharmacology from Central South University. After receiving his doctoral degree, Dr. Jin worked as a postdoctoral scholar at the University of California, San Francisco exploring effects of sphingolipids in cardiac protection. Dr. Jin taught Pharmacology for Pharm.D. students and Ph.D. students and carried out cardiovascular research as an Assistant Professor and a Ph.D. advisor at South Dakota State University College of Pharmacy.

At CNUCOP, Dr. Jin has taught Pathophysiology and Pharmacology II (Cardiovascular and Renal System) for Pharm.D. students since 2015 and Pharmacogenomics/Personalized Medicine since 2016.

Dr. Jin’s research focuses on dedifferentiation of cardiac myofibroblasts in cardiac fibrosis and role of cardiac microvascular endothelial cells in protection of the heart.

Research Interest

• Sphingolipids and S1P receptors
• Cardiac fibrosis and anti-fibrosis: differentiation and de-differentiation
• Cardiac microvascular endothelial cells: survival pathways
• Microfluidic device in studies of cell-cell interaction of the heart

Scholarship

Selected Peer-Reviewed Publications

• Malhotra A, Oh S, Jin Z, Feng X. Closing the integration gap: a pilot for incorporating foundational sciences, DEI-decision making, empathy, and communication for congestive heart failure and arrhythmia management by pharmacy students. Pharmacy. 2022; 10: 77.
• Luu VT, Phan S, Jin ZQ. Dedifferentiation of human cardiac myofibroblasts is independent of activation of COX-2/PGE2 pathway. Int J Mol Sci. 2022; 23: 3023.
• Jin ZQ. MicroRNA targets and biomarker validation for diabetes-associated cardiac fibrosis. Pharmacol Res. 2021; 174: 105941.
• Abdullah CS, Jin ZQ. Targeted deletion of T-cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin-induced diabetic mice. FASEB J. 2018; 32: 5426-5435.
• Abdullah CS, Li Z, Wang X, Jin ZQ. Depletion of T lymphocytes ameliorates cardiac fibrosis in streptozotocin-induced diabetic cardiomyopathy. Int Immunopharmacol. 2016; 39: 251-264.
• Li Z, Abdullah CS, Jin ZQ. Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy. Br J Pharmacol. 2014; 171: 2913-2924.
• Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. N-Terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PLoS ONE 2013; 8: e68154.
• Li Z, Jin ZQ. Ischemic preconditioning enhances integrity of coronary endothelial tight junctions. Biochem Biophy Res Commun. 2012 425: 630-635.
• Bandhuvula P, Honbo N, Wang G, Jin ZQ, Fyrst H, Zhang M, et al. S1P lyase (SPL): a novel therapeutic target for ischemia/reperfusion injury of the heart. Am J Physiol. Heart Cir Physiol. 2011; 300: H1753-H1761.
• Vessey DA, Li L, Jin ZQ, Kelley M, Honbo N, Zhang J, Karliner JS. A sphingosine kinase for 2 knockout sensitizes mouse myocardium to ischemia/reperfusion injury and diminishes responsiveness to ischemic preconditioning. Oxidative Medicine & Cellular Longevity. 2011; Article ID: 961059.
• Kotlyar AB, Randazzo A, Honbo N, Jin ZQ, Karliner JS, Cecchini G. Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase. FEBS Lett. 2010; 584: 159-65.
• Jin ZQ, Karliner JS, Vessey DA. Ischemic postconditioning protects isolated mouse hearts against ischemia/reperfusion injury via sphingosine kinase isoform 1 activation. Cardiovasc Res. 2008; 79: 134-140.
• Jin ZQ, Zhang J, Huang Y, Hoover HE, Vessey DA, Karliner JS. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Cardiovasc Res. 2007; 76: 41-50.
• Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Am J Physiol Heart Circ Physiol. 2006; 291: H1838-H1846.
• Jin ZQ, Karliner JS. N, N-Dimethylsphinjgosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCε dependent mechanism. Cardiovasc Res. 2006; 71: 725-734.
• Jin ZQ, Zhou HZ, Cecchini G, Gray MO, Karliner JS. Manganese superoxide dismutase in mouse heart: acute responses to ischemic preconditioning and ischemia/reperfusion injury. Am J Physiol. Heart Cir Physiol. 2005; 288: H2986-H2994.
• Jin ZQ, Goetzl EJ, Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation 2004; 110: 1980-1989.
• Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol. 2002; 282: H1970-1977.

Book Chapters

• Jin Z. Chapter 15. Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD). pages 339-356 in a book entitled “Macrophage Targeted Delivery Systems: Basic Concepts and Therapeutic Applications” edited by Drs. Swati Gupta and Yashwant Pathak and published by Springer International Publishing. 1st edition in February 2022. ISBN 978-030-84163-8.

Accomplishments and Awards

• Delegate of American Association of Colleges of Pharmacy (AACP) (2025)
• CNUCOP Seed Grant Award (2024)
• Researcher of the Year, California Northstate University College of Pharmacy (June 23rd, 2022)
• Certificate of Recognition for dedication service of five years at California Northstate University (12/23/2020)
• Travel Grant Award at the American Diabetes Association’s 74th Scientific Sessions (San Francisco, June 13-17, 2014)
• Fellowship (FAHA), Council on Basic Cardiovascular Sciences, American Heart Association (Nov. 2011)
• Member, Review Committee, American Heart Association (2010-2013)
• Trainee Abstract Award at the Scientific Sessions of American Heart Association (Nov.11-14, 2001, Anaheim, CA)
• The National Excellent Doctorate Dissertation Award of China (Aug. 2000)