Linh Ho, PharmBS, PhD

Department of Pharmaceutical and Biomedical Sciences
Associate Professor

Phone: (916) 686-7370
Fax: (916) 686-8142
Linh.Ho@cnsu.edu

About

Dr. Linh Ho is an Assistant Professor in the Department of Pharmaceutical & Biomedical Sciences at the California Northstate University College of Pharmacy. She received her B.S. in Pharmacy and M.S. in Pharmaceutical Sciences from University of Medicine and Pharmacy HCMC, and a Ph.D. in Chemistry and Chemical Biology program from University of California San Francisco (UCSF). Prior to joining California Northstate University, Dr. Ho continued her post-doctoral research at UCSF in regulation of mesenchymal stem cell fate, adipogenesis, and metabolic diseases of mitochondrial Sirtuin-3 as well as molecular mechanism of mitochondrial disease. Dr. Ho’s research focuses on targeting mitochondrial Sirtuins for treatment of type2 diabetes mellitus, obesity, and diseases including pulmonary arterial hypertension.

Research Interest

• Pathophysiological mechanisms and drug development for diseases including type 2 diabetes, obesity, and pulmonary hypertension
• Post translational modifications, acetylation/deacetylation, mitochondrial Sirtuins

Scholarship

• Oanh Ma and Truc Le, George Talbott, Tram HoangThao Nguyen, Dorothy Ha, Linh Ho. Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity. Pharmacology Research and Perspectives. Dec 2020.
• Linh Ho, Liping Wang, Theresa M. Roth, Yong Pan, Eric M. Verdin, Edward C Hsiao, Robert A. Nissenson. Sirtuin-3 promotes adipogenesis, osteoclastogenesis, and bone loss in aging male mice. Endocrinology. 12 July, 2017.
• Liping Wang, Theresa Roth, Marcia Abbot, Linh Ho, Lalita Wattanachanya, Robert A. Nissenson. Osteoblast-Derived FGF9 Regulates Skeletal Homeostasis. Bone. 2017 May; 98:18-25.
• Marcia J. Abbott, Theresa M. Roth, Linh Ho, Liping Wang, Dylan O’Carroll, Robert A. Nissenson. Negative Skeletal Effects of Locally Produced Adiponectin. PLoS One. 2015; 10(7):e0134290.
• Linh Ho, Allen Sam Titus, Philipp Gut, Wei Lin, Mingjian Fei, Kushal Banerjee, Asish K. Saha, Ken Nakamura, Eric Verdin, Ullas Kolthur Seetharam. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). Nov 2013; 5(11):835–849.
• Wirth M, Karaca S, Wenzel D, Linh Ho, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion. 2013 Feb 21.
• He W, Newman JC, Wang MZ, Linh Ho, Verdin E. Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab. 2012 Sep; 23(9):467-76.
• Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Linh Ho, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics. 2011 Dec; 10(12):M111.012658.
• Shimazu T, Hirschey MD, Huang JY, Linh Ho, Verdin E. Acetate metabolism and aging: An emerging connection. Mech Ageing Dev. 2010 Jul-Aug; 131(7-8):511-6.
• Huang JY, Hirschey MD, Shimazu T, Linh Ho, Verdin E. Mitochondrial sirtuins. Biochim Biophys Acta. 2010 Aug; 1804(8):1645-51.

Accomplishments and Awards

• Reviewer Recognition by Aging Research Reviews, 2019
• Featured Research of “Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice” on Endocrinology, 2017
• Plenary poster section award in ASBMR Seattle, Washington, 2015
• Stipend award in CSHL metabolic signaling and disease meeting, 2013
• MOET (Ministry of Education and Training) PhD fellowship, 2008-2010
• Research scholarship, PHRI (Public Health Research Institute), New Jersey, 2002-2003
• First Prize for Young Scientist in the National Science and Technology Conference for Medicine and Pharmacy Universities in Vietnam, 2002