Ashim Malhotra, PharmBS, MS, PhD, FAPE

Ashim Malhotra, PharmBS, MS, PhD, FAPE

Department of Pharmaceutical and Biomedical Sciences
Director, CNU Institute of Teaching and Learning Excellence
Coordinator, Interprofessional Education Program, CNUCOP
Director, Pharmacy Primer Program, CNUCOP
Associate Professor of Pharmacology
Department of Pharmaceutical & Biomedical Sciences
Assistant Dean of Curriculum and Program Development
Associate Professor-Molecular Physiology and Biochemistry

Phone: (916) 686-8885
Fax: (916) 686-8142
Ashim.Malhotra@cnsu.edu


About

Dr. Ashim Malhotra is a pharmacist, NYU-trained molecular pharmacologist, and a pharmacy educator. At CNU, he serves as the Director of the university-level Institute of Teaching and Learning Excellence (ITLE), which operates under the aegis of the Office of the University Vice President of Academic Affairs. In this role, he leads faculty development activities for the five CNU colleges of Medicine, Pharmacy, Health Sciences, Psychology, and Dental Medicine. He is also the coordinator of Interprofessional Education for the university and the CNUCOP, the Director of the CNUCOP’s Pharmacy Primer Program, and an associate professor of pharmacology at the CNUCOP. He earned his Bachelor of Pharmacy degree in 2000, M.S. (2003), and Ph.D. specializing in Molecular Pharmacology from St. John's University in New York City (2006). From the next five years, he worked as a postdoctoral fellow and a senior research scientist at the New York University School of Medicine in molecular pharmacology.

His many professional contributions have been recognized through 28 college, university and national awards as of 2020, of which 13 are teaching-related; for example, he was the “Teacher of the Year” at every institution where he has worked. His teaching interest includes transplant medicine, immunology, cardiovascular pathophysiology and pharmacology, renal diseases, and interprofessional education (IPE). He is also interested in SOTL, particularly in developing novel interprofessional teaching tools and assessment methodologies in pharmacy education. Dr. Malhotra has a rich history of mentoring Pharm.D. and undergraduate students and postdoctoral fellows in bench and pedagogy research. For five years in a row, work conducted by his students was recognized through national awards such as the 2019 AACP Walmart Scholar award, 2015-2018 American Society of Pharmacology and Experimental Therapeutics (ASPET) travel awards, 2017 First prize winner at the Dolores Shockley ASPET poster competition, and others. He has published twenty-one peer-reviewed journal articles, thirteen book chapters, one book, over 50 abstracts, and has garnered $304,000 in research funding with an emphasis on mitochondrial pharmacology. Additionally, he has been invited to present at over three dozen conferences. His research focuses on elucidating mitochondrial mechanisms in the etiology, pathological progression, and treatment of diseases such as cardiomyopathy, pancreatic cancer, and infectious diseases. His work has been cited more than 1,100 times and he has an H-index of 11 as of 2020.

Some instances of college, university, and national service include his roles as Chair of the ACPE Self-Study for CNUCOP, Chair of Strategic Planning Committee for CNUCOP, Chair of college (Assessment; Marketing and Alumni; and Scholarship and Awards), university (Diversity), and national committees; service on the University Faculty Senate; Chair for ACPE Standard 11, IPE and diversity Self-Study contributor for LCME accreditation for College of Medicine and CODA accreditation for the College of Dental Medicine, and as a member of the University Accreditation Steering Committee for WASC accreditation.

Research Interest

I am a combination pharmacist, molecular pharmacologist, and pharmacy educator. I am interested in investigating the role of mitochondria in human health and disease, most recently for pancreatic cancer. I have examined mitochondrial form and function in diseases such as pediatric cardiomyopathy, infectious diseases, and cancer. Through my research endeavors, I have trained undergraduate and Pharm.D. students and postdoctoral fellows in bench research, which has been continually recognized by national awards. Specifically, I am actively investigating repurposing FDA-approved drugs for use in pancreatic cancer to enable the discovery of novel mitochondria-based therapeutic targets, with the intention of targeting metabolic signals to exploit vulnerabilities in chemoresistant cancers.

Scholarships

Peer-reviewed Journal Articles
  • 2020: Titus-Lay E, Eid T, Kreys T-J, Chu BXJ, Malhotra A. Trichotillomania associated with a 25-hydroxy vitamin D deficiency. A Case Report. Ment Health Clin. 2019; 9 (6).
  • 2019: Hughes J, Cleven A, Ross J, Fuentes D, Elbarbry F, Suzuki M, Paolera MD, Carter NS, Stamper B, Low P, Malhotra A, Faro SJE. A Comprehensive Reflective Journal- Writing Framework for Pharmacy Students to Increase Self-Awareness and Develop Actionable Goals. Am J Pharm Educ. 83 (3).
  • 2017: Stamper BD, Buhler AV, Harrelson JP, Roberts SC, Malhotra A, Elbarbry FA, Rao D, Karimi R, Turner R, Marlow C, Devaud LL. Forecasting academic success through implementation of an online prerequisite review tutorials program for first-year pharmacy students. Curr Pharm Teach Learn. 9 (2): 261-271.
  • 2017: Amawi H, Karthikeyan C, Pathak R, Hussein N, Christman R, Robey R, Ashby CR Jr, Trivedi P, Malhotra A, Tiwari A. Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe. Eur J Med Chem. 29; 138: 1053-1065. (Impact Factor: 4.519).
  • 2016: *Bath S, Lines J, Loeffler AM, Malhotra A, Turner RB. Impact of standardization of antimicrobial prophylaxis duration in pediatric cardiac surgery. J Thorac Cardiovasc Surg. 152 (4): 1115-20. (Impact Factor: 4.168).
  • 2015: Xu Y, Malhotra A, Claypool S, Ren M, Schlame M. Tafazzin from Drosophila and mammalian cells: assembly in large protein complexes with a short half-life. Mitochondrion. 21:27-32. (Impact Factor: 3.8).
  • 2015: Turner RB, Martello J, Malhotra A. Worsening renal function in patients with baseline renal impairment treated with intravenous voriconazole: a systematic review. Int J Antimicrob Agents. S0924-8579 (15) 00251-4. (Impact Factor: 4.28).
  • 2015: Malhotra A, Bath S*, Elbarbry F. An organ system approach to exploring the antioxidative, anti-inflammatory, and cytoprotective actions of resveratrol. Oxid Med Cell Longev. 2015: 803971. (Impact Factor: 4.49). Review.
  • 2014: Malhotra A, Kahlon P*, Donoho T, Doyle IC. Pharmacogenomic considerations in the treatment of the pediatric cardiomyopathy called Barth Syndrome. Recent Pat Biotechnol. 8 (2): 136-43.
  • 2014: Turner BR, Grover A, Malhotra A. The clinical management of pancreatic cancer. U.S. Pharmacist. Hematology and Oncology Supplement. September. Newsletter.
  • 2014: Fulford MJ, Souza J, Alston GL, McLaughlin J, Garavalia L, Franson K, Fowles M, Malhotra A, Szilagyi J, Kelley K, Castleberry A, Peeters M, Jenkins T, Bloom TJ, McDonough S, DiVall M, Marsh W, Dintzner M, Ried LD, Stratton T, Alkhateeb FM, Boyce E, Fox L, Dolaresco F, Bernard D, Coyne L, Ofstad W, McEwen D, Bouldin A, Mintz K, Zeszotarski P. Are you CAPE-A.B.L.E.? Center for the Advancement of Pharmacy Education: An assessment blueprint for learning experiences. A white paper on CAPE assessment. American Association of the Colleges of Pharmacy.
  • 2011: Acehan D, Malhotra A, Xu Y, Ren M, Schlame M. Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria. Biophys J. 100 (9): 2184-92. (Impact Factor: 4.137).
  • 2011: Bedrosian AS, Nguyen AH, Hackman M, Connolly MK, Malhotra A, Ibrahim J, CiezaRubio NE, Henning JR, Barilla R, Rehman A, Pachter HL, Medina-Zea MV, Cohen SM, Frey AB, Acehan D, Miller G. Dendritic Cells Promote Pancreatic Viability in Mice with Acute Pancreatitis. Gastroenterology. 141 (5): 1915-26. (Impact factor: 12.455).
  • 2011: Connolly M, Ayo D, Malhotra A, Hackman M, Ibrahim J, Bedrosian AS, Cieza-Rubio NE, Henning JR, Pachter HL, Frey AB, Miller G. Dendritic cell depletion exacerbates acetaminophen hepatotoxicity. Hepatology. 54 (3): 959-68. (Impact factor: 11.665).
  • 2010: Connolly MK, Bedrosian AS, Malhotra A, Henning JR, Ibrahim J, Vera V, Cieza-Rubio NE, Hassan BU, Pachter HL, Cohen S, Frey AB, Miller G. In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity. J Immunol. 185 (4): 2200-8. (Impact factor: 5.788).
  • 2009: Connolly M, Mallen-St.Clair J, Bedrosian A, Malhotra A, Vera V, Ibrahim J, Pachter L, Bar-Sagi D, Frey A, Miller G. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and pre-invasive intra-abdominal tumor. J Leuk Bio. 87 (4): 713-25. (Impact factor: 4.992).
  • 2009: Xu Y, Zhang S, Malhotra A, Edelman-Novemsky I, Ma J, Kruppa A, Cernicica C, Blais S, Neubert TA, Ren M, Schlame M. Characterization of tafazzin splice variants from humans and fruit flies. J Biol Chem. 284 (42): 29230-9. (Impact factor: 4.8).
  • 2009: Malhotra A, Xu Y, Ren M, Schlame M. Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species. Biochimica et Biophysica Acta - 1791 (4): 314-20. (Impact factor: 3.883).
  • 2009: Malhotra A, Edelman-Novemsky I, Xu Y, Plesken H, Ma J, Schlame M, Ren M. Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome. Proc Natl Acad Sci U S A. 106 (7): 2337-41. (Impact factor: 9.681).
  • 2009. Acehan D, Khuchua Z, Houtkooper RH, Malhotra A, Kaufman J, Vaz FM, Ren M, Rockman HA, Stokes DL, Schlame M. Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion. 9 (2): 86-95. (Impact factor: 4.108).
  • 2006. Xu Y, Malhotra A, Ren M and Schlame M. The enzymatic function of tafazzin. J Biol Chem. 281 (51): 39217-24. (Impact factor: 4.8).
Book
  • 2017: Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research”, Malhotra A and Soni S (Editor), IGI Global, Hershey, Pennsylvania.
Book Chapters
  • 2020: Javan G, Finley S, Malhotra A, Soni S. Dioxins: Detailed insight into their role as carcinogens, In: Dioxin-Environmental Fate, Human Health and Ecological Consequences. CRC press.
  • 2018: Khan F, Malhotra A. Review of bioorganic chemistry, In Medicinal Chemistry for Pharmacy Students, volume 1: Fundamental Concepts of Medicinal Chemistry and Drug Metabolism. F Khan (Editor), Bentham.
  • 2017: Malhotra A, Soni S. Examining the effect of mitochondrial fission and fusion events on the heart: the role of the mitochondria in heart diseases, In Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research. Malhotra A and Soni S (Editors), IGI Global, Hershey, Pennsylvania.
  • 2017: Badejo A, Malhotra A. Antioxidant nutraceuticals in the treatment of inflammatory diseases, In Antioxidant Nutraceuticals: Preventive and Healthcare Applications. S. Pathak (Editor), Taylor and Francis (CRC Press).
  • 2016: Malhotra A. Nanotechnology-based nutraceuticals and functional foods used in cardiovascular disease, In Nanotechnology in Nutraceuticals and Functional Foods - Production to Consumption. Y. Pathak (Editor), Taylor and Francis.
  • 2016: Malhotra A, Javan G, Soni S. Applications of biopolymer based surface modification in cardiovascular science, In Handbook of Pharmaceutical Polymers. A. Tiwari (Editor), Wiley-Scrivener USA.
  • 2015: Malhotra A. Introduction to pharmacogenomics, In Pharmacotherapeutics for Nurse Practitioner Prescribers, 4thed. TM Woo and ML Robinson (Editors), FA Davis, Philadelphia.
  • 2015: Malhotra A. Improving matters of the heart: pharmaceutical polymer applications in cardiology, In Handbook of Pharmaceutical Polymers. VK Thakur and MK Thakur (Editors), Wiley.
  • 2015: Javan GT, Finley SJ, Can I, Salhotra A, Malhotra A, Soni S. Aberrant signaling pathways: hallmark of cancer cells and target for nanotherapeutics, In Advanced Theranostic Materials. A Tiwari, HK Patra, J-W C (Editors), Wiley.
  • 2015: Doyle IC, Malhotra A. Polymers used in augmenting immunosuppressive therapy, In Handbook of Polymers for Pharmaceutical Technologies. VK Thakur (Editor), Wiley.
  • 2014: Malhotra A. Cardiology applications in nanotechnology: proof of principle, In Handbook of Research in Nanotechnology Applications. S. Soni, A Salhotra, M Suar (Editors), IGI Global.
Chapters accepted for publication, 2020
  • Malhotra A. Pharmaceutical liquid dosage forms in space: looking towards the future by learning from the past, In: Handbook of Space Pharmaceuticals. Pathak YV, Araújo dos Santos M, Zea L (Editors). Springer.
  • Malhotra A, Khan F. Pharmacology of immunosuppressive agents and miscellaneous drugs, In Medicinal Chemistry for Pharmacy Students. F Khan (Editor), Bentham.

Accomplishments & Awards

  • 2019-20 Professor of the Year, CNU College of Pharmacy (CNUCOP)
  • 2019 University President’s Recognition, California Northstate University (CNU) For “Leadership in Program Development”
  • 2019 University Vice President’s Award for Leadership in Interprofessional Education California Northstate University (CNU), Elk Grove, CA
  • 2019 Faculty Service Award, CNU College of Pharmacy
  • 2019 Scholar of the Year, CNU College of Pharmacy
  • 2019 Teacher of the Year, P2, First Runner-up, based on student votes, California Northstate University (CNU) College of Pharmacy
  • 2019 Exam Writer, National Association of the Boards of Pharmacy (NABP)
  • 2018 Abstract selected for ASPET oral presentation in program titled “Can metabolic vulnerabilities in cancer cells be therapeutically exploited?”
  • 2017 Invited as Keynote speaker at Chronic Diseases 2017 meeting in Brussels, Belgium
  • 2017 Pharmacology Educators Travel Award, ASPET
  • 2017 Teacher of the Year, Students’ Choice Award, Runner-up
  • 2017 Chair, Alumni and Marketing Committee, School of Pharmacy, Pacific University
  • 2017 Mentored research award: First Prize to my postdoctoral fellow in the national ASPET Shockley graduate student and postdoc competition
  • 2016 Pacific University President’s Junior Faculty Award
  • 2016 AACP Teacher of the Year, School of Pharmacy, Pacific University
  • 2016 Nominated for Pacific University Award for Excellence in Graduate Teaching
  • 2016 Pacific University Authors’ Celebration: special mention for prolific productivity
  • 2016 National Science Foundation (NSF) Grant Reviewer, Graduate Research Fellowship Panel, Cell Biology Study Section
  • 2016-19 Member, University Faculty Senate
  • 2016 Best Poster Award, Pacific University Undergraduate Research Conference
  • 2016 Co-Chair, Diversity task force, College of Health Professions, Pacific University
  • 2014-16 Chair, Subcommittee on Strategic Planning, Biological Sciences Section, AACP
  • 2014 Chair, Assessment Committee, School of Pharmacy, Pacific University
  • 2014 Winner, AACP “Innovations in Teaching” national award competition as a member of a team of pharmacology faculty
  • 2014 Co-author and participant for national white paper in assessment strategies for CAPE domains in pharmacy education; published by AACP
  • 2012 Best Faculty Award, New York Methodist Hospital Center for Allied Health Education, Brooklyn, New York
  • 2011 Marquis Who’s Who in Medical Education in USA
  • 2011 Marquis Who’s Who in Science in USA
  • 2008 Best Poster Award, American Society of Biochemistry and Molecular Biology
  • 2007 Best Paper Award, Experimental Biology Meeting
  • 2005 Travel Award, ASBM
  • 2004 Best Graduate Poster Award, ASBMB
  • 2003 Best Graduate Poster Award, ASBMB
  • 2000 Gold Medalist in undergraduate pharmacy, School of Pharmacy, Hamdard University
  • 1997 Elected Literary Secretary of Hamdard University
  • 1996 Hakeem Abdul Hameed Chancellor Award & Gold Medal, School of Pharmacy, Hamdard University, New Delhi, India
  • ASPET: American Society of Pharmacology and Experimental Therapeutics
  • AACP: American Association of Colleges of Pharmacy
  • ASBMB: American Society of Biochemistry and Molecular Biology